IndraLab

Statements

Ivabradine hydrochloride inhibits HCN4. 8 / 9
1 | 7
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"HCN4 was blocked by the application of 2mM Cs + or 10muM ivabradine."
19729016
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"Most interesting, a recent report (Bucchi et al., 2006) indicates that ivabradine blocks HCN1 in a use dependent manner via the closed state, but HCN4 via a voltage dependent, open state mechanism."
18162181
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"In streptozotocin induced diabetic mice, ivabradine treatment significantly inhibited left ventricular hyperpolarization activated cyclic nucleotide gated channel 2 (HCN2) and HCN4 (major components of the I f current), activated PP2Ac, and attenuated NF-kappaB signaling activation and apoptosis, in line with improved histological abnormalities, fibrosis, and cardiac dysfunction without affecting hyperglycemia."
30998977
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"Given its clinical use, it is important to understand the molecular details of ivabradine block of HCN4 channels, the main isoform expressed in the pacemaker region of the heart."
23308150
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"Properties of ivabradine induced block of HCN1 and HCN4 pacemaker channels."
16484306
dgi
No evidence text available
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"Our findings confirm and extend observations in genetic conditions associated with altered HCN4 function and clinical trials with the HCN4 blocker ivabradine XREF_BIBR, XREF_BIBR."
29773827
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"Some HCN4 blockers such as ivabradine have been extensively studied for treating various heart diseases."
34041946