IndraLab

Statements

Ivabradine hydrochloride inhibits HCN4. 5 / 6
| 5
reach
"Given its clinical use, it is important to understand the molecular details of ivabradine block of HCN4 channels, the main isoform expressed in the pacemaker region of the heart."
23308150
reach
"Our findings confirm and extend observations in genetic conditions associated with altered HCN4 function and clinical trials with the HCN4 blocker ivabradine XREF_BIBR, XREF_BIBR."
29773827
reach
"Properties of ivabradine induced block of HCN1 and HCN4 pacemaker channels."
16484306
reach
"HCN4 was blocked by the application of 2mM Cs + or 10muM ivabradine."
19729016
reach
"Most interesting, a recent report (Bucchi et al., 2006) indicates that ivabradine blocks HCN1 in a use dependent manner via the closed state, but HCN4 via a voltage dependent, open state mechanism."
18162181