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PDGF increases the amount of USP7. 4 / 4
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"Fig. 2a indicates that PDGF increased the protein level of USP7 by 1.50-fold compared with control (P < 0.05)."
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", In the present study, we found that PDGF increased the expression of USP7; silencing of USP7 attenuated PDGF-induced PASMCs proliferation, suggesting that USP7 mediates PDGF-stimulated PASMCs proliferation.USP7 has been reported to deubiquitinate several targeted proteins such as MDM2, UHRF1, DNMT1, claspin and PTEN, and thereby suppress their ubiquitinated degradation or the regulation of their subcellular localization."
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"This result suggests that PDGF up-regulates USP7, MDM2 and CyclinD1 protein expression while down-regulates FoxO4 expression in PASMCs."
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"Our results indicated that PDGF up-regulated USP7 protein expression and stimulated PASMCs proliferation; this was accompanied with the increase of MDM2, forkhead box O4 (FoxO4) reduction and elevation of CyclinD1."
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