IndraLab

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MCF2L2 activates KCNA2. 7 / 7
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"Mechanistically, MZF1 participated in CCI-induced reductions in Kv1.2 mRNA and protein and total potassium current and in the CCI-induced increase in neuronal excitability through MZF1-triggered Kv1.2 AS RNA expression in the injured DRG neurons."
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"Mechanistically, MZF1 participated in CCI-induced reductions in Kv1.2 mRNA and protein and total Kv current and the CCI-induced increase in neuronal excitability through MZF1-triggered Kv1.2 AS RNA expression in the injured DRG neurons."
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"Specifically, in injured DRG, DNMT3a facilitates methylation levels at the Oprm1 promoter region leading to gene silencing and, similarly at the promotor region of voltage-gated K channel Kcna2 gene via activation of the transcription factor octamer transcription factor 1 [26]."
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"This increase contributed to CCI-induced neuropathic induction and maintenance by transcriptionally activating Ehmt2 and subsequently epigenetic silencing of Oprm1 (which encodes MOR) and Kcna2 (which encodes Kv1.2) genes in the ipsilateral DRG."
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"Mechanistically, MZF1 participated in CCI-induced reductions in Kv1.2 mRNA and protein and total Kv current and the CCI-induced increase in neuronal excitability through MZF1-triggered Kv1.2 antisense RNA expression in the injured DRG neurons."
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"This anti-hyperalgesic effect may be related to the functional role of MZF1 in nerve injury-induced down-regulation of Kv1.2 mRNA and protein triggered by Kv1.2 AS RNA in the injured DRG."
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"Moreover, Zhao et al. have recently identified a functional lncRNA Kcna2, which contributed to neuropathic pain by silencing Kcna2 in DRG neurons [18]."
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