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TGFB activates USP15. 15 / 15
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"In the presence MG132 that inhibits proteasome activity, treatment with TGF-beta increases USP15 production (XREF_FIG)."
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"TGF-beta upregulates the translation of USP15 through a non smad pathway."
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"TGF-beta promotes USP15 production."
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"For example, TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability [39]."
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"23 However, in advanced cancer, TGF-beta signaling can also mediate USP15 to promote oncogenesis."
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"There are several reports implying that TGF-beta may upregulate USP15."
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"Upregulation of USP15 by TGF-beta was also observed in HEK293 cells (XREF_FIG)."
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"It is known that TGFbeta upregulates the protein translation of USP15 in a PI3K and Akt dependent manner."
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"TGF-beta promotes the translation of USP15 through activation of mammalian target of rapamycin by the phosphoinositide 3-kinase/AKT pathway."
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"Taken together, TGF-beta enhanced USP15 production was due to upregulation of its translation and not by suppression of USP15 degradation."
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"31 We have also demonstrated that TGF-beta signaling can upregulate USP15 synthesis (XREF_FIG)."
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"Upregulation of USP15 by TGF-beta is not due to an increase in USP15 transcription."
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"In this study, we demonstrate that TGF-beta can upregulate the translation of USP15 through the PI3K and AKT pathway, in turn resulting in stabilizing p53 through deubiquitination."
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"Recently, it has been shown that TGFbeta upregulates the translation of USP15 suggesting a positive feedback loop, however, the extent of the TGFbeta activity also regulates the access of USP15 to the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TGF-beta upregulates the translation of USP15 via the PI3K and AKT pathway to promote p53 stability."
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