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PSMD14 activates cell population proliferation. 64 / 64
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"The colony formation assay confirmed that POH1 silencing reduced cell proliferation in HCC, EC, and CRC, as the number of colonies formed by POH1 silenced cells was much lower than that in the control groups (XREF_FIG C)."
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"MTT and colony formation assays revealed that the overexpression of POH1 failed to promote cell proliferation (XREF_FIG E-F)."
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"The CCK8 assay revealed that PSMD14 depletion inhibited cancer cell proliferation in MCF-7, T47D and MDA-MB-175 cells (Fig. 2C, Fig S1E, F)."
38017133
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"In cancer progression, high levels of PSMD14 also enhanced the proliferation, migration and invasion cancer cells, such as breast cancer , ovarian cancer , bladder cancer , etc."
40025166
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"In conclusion, these findings suggest that PSMD14 may stimulate bladder cancer cell proliferation by promoting mitochondrial fission through the stabilization of Drp1."
37975230
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"The CCK8 assay revealed that overexpression of PSMD14 promoted cancer cell proliferation in MCF-7 cells (Fig. 2I)."
38017133
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"Depletion of PSMD14 suppresses bladder cancer proliferation by regulating GPX4."
36632137
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"Gain and loss of function experiments demonstrated that PSMD14 deficiency inhibited bladder cancer cell proliferation."
36632137
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"PSMD14 knockdown inhibits in vitro cell proliferation, migration, invasion, and in vivo tumor growth."
38053170
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"Depletion of PSMD14 could inhibit the proliferation of bladder cancer cells through the downregulation of GPX4."
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"Moreover, we established anlotinib-resistant osteosarcoma sublines and verified that PSMD14 was significantly expressed in the sublines and that PSMD14 knockdown could reduce the proliferation, migration, and invasion of resistant lines, as well as reverse anlotinib resistance."
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"The expression of PSMD14 is significantly higher in hepatocellular carcinoma than in normal liver tissues, and the knockdown of PSMD14 expression inhibited hepatocellular cancer proliferation and metastasis by down-regulation of GRB2 (Lv et al., 2020)."
36632137
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"PSMD14 promotes the proliferation, migration, and invasion of TNBC cells."
40344056
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"Knockdown and overexpression experiments elucidated that PSMD14 stimulated OV cell proliferation, invasion and migration in vitro."
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"The results showed that overexpression of PSMD14 increased the proliferation ability of the BT-549 and HCC1937 cells (Fig. 2, C, D, F, and H, and fig."
40344056
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"PSMD14 overexpression was found to promote the proliferation, invasion, migration of HTR-8/SVneo cells and the angiogenesis of HUVECs following treatment with the HTR-8/SVneo cell culture supernatant, accompanied by enhanced expression of proliferation and migration-related proteins."
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"The results of biological function assays showed that PSMD14 silencing markedly decreased proliferation, migration, and invasiveness, but these effects were reversed in the TNBC cells co-transfected with sh-PSMD14 and FADS1-expressing plasmids (Fig. 6, A to D, and fig."
40344056
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"PSMD14 can promote phenotypic changes in HCC cells in vitro, including affecting cell proliferation invasion and migration."
37853322
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"Our results showed that PSMD14 overexpression promoted BC cell proliferation."
36632137
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"PSMD14 promoted BC cell proliferation in vitro and in vivo."
36632137
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"PSMD14 knockdown plus anlotinib treatment significantly inhibited the proliferation, invasion, and migration of resistant sublines compared to anlotinib or PSMD14 knockdown treatment alone."
38053170
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"As reported by Zhang et al. , PSMD14 enhanced the proliferation as well as invasion of trophoblast, which might be a potential targets for PE treatment."
40025166
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"As expected, the promotion of cell proliferation induced by PSMD14 overexpression was reversed when BC cells were treated with RSL3, as shown by the CCK-8 assay (Fig. 7C)."
36632137
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"POH1 depletion, for example, has been shown to impair multiple myeloma cell proliferation [190]."
32708614
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"In vitro, PSMD14 overexpression stimulated osteosarcoma cell proliferation."
38053170
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"In conclusion, HEY1-activated PSMD14 promoted trophoblast proliferation, invasion and angiogenesis."
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"Furthermore, western blotting results revealed that PSMD14 overexpression significantly promoted the expression of proliferation markers Ki67 and PCNA in HTR-8/SVneo cells (Fig. 1E)."
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"Zhang et al. [17] discovered that suppression of PSMD14 inhibits cell proliferation, G1 arrest, and cellular senescence while boosting cell death by upregulating p21 stability and cleaved caspase-3."
38053170
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"PSMD14 overexpression was found in the present study to promote the proliferation of HTR-8/SVneo trophoblast cells."
35761814
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"PSMD14 knockdown inhibited PC cell viability, proliferation, migration, and invasion."
40066751
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"In our study, we revealed for the first time that the knockdown of PSMD14 could inhibit the proliferation and colony formation of BC cells by targeting GPX4."
36632137
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"Functionally, PSMD14 promotes the proliferation and invasiveness of ATC cells, whereas the depletion of PSMD14 or PSMD14 inhibitor thiolutin (THL) inhibits the growth, invasiveness, and epithelial-mesenchymal transition ((EMT) of ATC cells."
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"Furthermore, elevated PSMD14 expression has been observed in breast cancer tissues compared with that in adjacent non-tumor tissues, such that PSMD14 knockdown was found to inhibit proliferation and migration whilst facilitating apoptosis and G /G arrest (29)."
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"Further in vivo and clinical studies are required to verify the findings in the present study.In conclusion, the present study demonstrated that HEY1 can activate PSMD14 expression, thereby promoting trophoblast proliferation, invasion and migration, in addition to downstream endothelial angiogenesis."
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"We preliminarily found that the depletion of PSMD14 inhibited the proliferation of BC cells by reducing GPX4, but the mechanism by which PSMD14 regulates GPX4 requires further study.There were some limitations in this study."
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"Furthermore, we observed that PSMD14 promoted proliferation, migration, and invasion in vitro and tumor growth metastasis in vivo by stabilizing GRB2 protein."
31634528
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"Depletion of PSMD14 could inhibit BC proliferation through down-regulation of GPX4."
36632137
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"In addition, PSMD14 can promote phenotypic changes in HCC cells in vitro, fostering cell proliferation invasion and migration."
38275386
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"The reciprocal effects of knockdown and overexpression of PSMD14 in vitro suggested that PSMD14 enhanced the proliferation ability of HCC cells."
31634528
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"The protein p53 has been demonstrated to be involved in PSMD14-mediated cell proliferation [ 33 ]."
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"Nevertheless, we found that knockdown of PSMD14 led to an obvious decrease in the proliferation capacity of Hep3B cells (p53 deficient), indicating that PSMD14 promoted the proliferation of HCC cells [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"PSMD14 knockdown inhibited human bladder cancer cell proliferation and improved cisplatin sensitivity in vitro and in vivo."
40121994
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"The CCK-8 assay showed that PSMD14 inhibition significantly reduced the proliferation rate of T24 and UMUC3 cells, both with and without cisplatin treatment (Fig. 3A)."
40121994
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"PSMD14 knockdown notably inhibited cell proliferation , migration , and invasion in vitro , which was confirmed through in vivo experiments ."
35405117
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"In addition, Zhi et al. pointed out that PSMD14 promoted the proliferation of glioma through stabilizing E2F1 [ 34 ]."
35405117
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"In summary, the results suggest that PSMD14 promotes bladder cancer cell proliferation both in vitro and in vivo."
40121994
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"Here, our findings showed that PSMD14 promoted in vitro proliferation, migration, and invasion of HCC cells, and facilitated tumor growth and metastasis in vivo ."
31634528
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"The knockdown of POH1 significantly inhibited tumor cell proliferation and induced apoptosis mediated by the mitochondrial pathway in vitro."
29573636
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"The results of this study showed that knockdown of PSMD14 inhibited proliferation and tumorigenicity of GC cells."
35405117
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"Knockdown of PSMD14 in osteosarcoma cells reduced the viability, proliferation, and invasion activities of osteosarcoma cells in vitro."
38863002
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"PSMD14 was reported to promote cell proliferation in vitro and larger xenograft tumor formation in vivo [38]."
35884607
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"It was reported that PSMD14 depletion could suppress cell proliferation in several cancers, such as bladder cancer [19], osteosarcoma [32] and ovarian cancer [13]."
39392083
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"Consistently, our findings demonstrate that POH1 promotes cell proliferation, invasion, and metastasis in NSCLS by mediating Smad3 stability."
38061486
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"In conclusion, PSMD14 promotes bladder cancer proliferation, progression, and cisplatin resistance by regulating NCL to activate the YAP1/Hippo pathway (Fig. 9)."
40121994
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"In summary, PSMD11 and PSMD14 could promote the proliferation, invasion, and migration of PDAC cells."
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"Recent studies have demonstrated that p53 is involved in PSMD14 mediated cell proliferation; p53 is upregulated in PSMD14-knockdown cells, and knockdown of PSMD14 induces cancer cell apoptosis mediated via p53 XREF_BIBR."
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"Recently, a study found that the expression of PSMD14 is reduced in PE patients, and upregulation of PSMD14 expression promoted the proliferation and invasion of placental trophoblast cells ."
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"Knockdown of PSMD11 and PSMD14 significantly inhibited the proliferation, migration, and invasion ability of pancreatic cancer cells."
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"CARM1 was important for PSMD14-enhanced proliferation, migration, and invasion in HCC cells."
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"Knockdown of PSMD11 and PSMD14 reduces PDAC cell proliferation, invasion and migration."
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"Indeed, overexpression of PSMD14 promoted proliferation and cell viability together with other pro-tumoral properties such as migration and invasion [ 39 , 49 , 52 ]."
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"Cell Counting Kit (CCK) assays indicated that depletion of PSMD14, NSD2, or RELA inhibited cell proliferation, whereas PSMD14 overexpression promoted the proliferation of LP-1 cells, an effect that wa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"O-phenanthroline (OPA) and Capzimin, small molecule inhibitors of PSMD14, can inhibit the proliferation of multiple myeloma cells and overcome bortezomib resistance."
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"Additionally, PSMD14-promoted cell proliferation appeared to be associated with its transcriptional activation of RELA , as knocking down RELA abolished, at least partially, the effect ( Figure 5 B)."
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