IndraLab

Statements

USP22 inhibits cell death. 3 / 3
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"Moreover, USP22, SIRT1, or SLC7A11 elevation contributed to enhanced cardiomyocyte viability and attenuated ferroptosis induced cell death in vitro, accompanied by increased GSH levels, as well as decreased reactive oxygen species production, lipid peroxidation, and iron accumulation."
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"USP22 inhibition restores cisplatin sensitivity in cisplatin-resistant lung cancer cells.Cisplatin can induce cell death by activating mitochondrial apoptosis."
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"In our study, after treatment with FO, the expression of USP22 was markedly increased, and the increase in USP22 increased the activity of Sirt1 and decreased myocardial cell death."
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