IndraLab

Statements

USP16 binds PLK1. 17 / 20
4 | 6 7
sparser
"Next, we treated HeLa cells with CDK1 inhibitor RO3306 and observed a significant reduction in Plk1–Usp16 interaction ( xref )."
26323689
sparser
"Because Usp16 interacts with Plk1, we suspected that it might deubiquitinate Plk1."
26323689
sparser
"Collectively, our results strongly suggest that CDK1 promotes the interaction between Plk1 and Usp16 and enhances the phosphorylation of Usp16 by Plk1."
26323689
reach
"Collectively, our results strongly suggest that CDK1 promotes the interaction between Plk1 and Usp16 and enhances the phosphorylation of Usp16 by Plk1."
26323689
sparser
"These data strongly suggest that the phosphorylation of S552 by CDK1 promotes Plk1–Usp16 interaction."
26323689
biogrid
No evidence text available
26323689
reach
"Recently, CDK1 dependent phosphorylation of Usp16 on S552 was shown to promote an interaction between Usp16 and Plk1."
28380042
biogrid
No evidence text available
26323689
sparser
"Because Usp16 is phosphorylated by CDK1 ( xref ; xref ), we speculated that CDK1 might serve as a priming kinase regulating Plk1–Usp16 interaction in a way similar to other cases ( xref ; xref )."
26323689
reach
"To identify any deubiquitylases that may deubiquitinate Plk1 in early mitosis, we performed reciprocal coimmunoprecipitation (coIP) assays and found that Usp16 specifically interacted with Plk1 in nocodazole arrested prometaphase HeLa cells (XREF_FIG)."
26323689
sparser
"To identify any deubiquitylases that may deubiquitinate Plk1 in early mitosis, we performed reciprocal coimmunoprecipitation (coIP) assays and found that Usp16 specifically interacted with Plk1 in nocodazole-arrested prometaphase HeLa cells ( xref )."
26323689
reach
"Usp16 interacts with and deubiquitinates Plk1."
26323689
reach
"Because Usp16 interacts with Plk1, we suspected that it might deubiquitinate Plk1."
26323689
reach
"Examination of the GST pull-down complexes showed that Usp16 specifically interacted with the wild-type (WT) PBD but not the PBD2A mutant (XREF_FIG), indicating that the interaction between Plk1 and Usp16 is PBD dependent."
26323689
biogrid
No evidence text available
26323689
biogrid
No evidence text available
26323689
sparser
"Examination of the GST pull-down complexes showed that Usp16 specifically interacted with the wild-type (WT) PBD but not the PBD2A mutant ( xref ), indicating that the interaction between Plk1 and Usp16 is PBD dependent."
26323689