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"Additionally, preclinical studies have demonstrated that chronic ethanol reduces the function and trafficking of K Ca 2 (Kcnn), K V 4.2 (Kcnd2), and K V 7.2 (Kcnq2) channels in the nucleus accumbens (NAc) and hippocampus, and pharmacologically enhancing K Ca 2 and K V 7 channel function attenuated voluntary drinking in rodents."