IndraLab

Statements

USP38 activates MYC. 6 / 6
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"Functionally, USP38 promotes cell proliferation in a c-Myc dependent manner."
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"Surprisingly, we found that knockdown of USP38 also notably decreased the c-Myc protein levels ( Fig. 1 A)."
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"We found that USP38 no longer increased the levels of c-Myc in the presence of the proteasome inhibitor MG132 ( Fig. 2 A), suggesting that USP38 prevents proteasomal degradation of c-Myc."
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"In addition, USP38 has been shown to promote cell proliferation by stabilizing LSD1 or c-Myc proteins27, 28."
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"USP38 is able to enhance the stability of c-Myc by antagonizing the function of FBW7α."
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"In addition, USP38 promotes lung cancer cell proliferation by stabilizing c-Myc (14)."
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