IndraLab

Statements

KCNQ1 inhibits Neoplasm Invasiveness. 8 / 8
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"Moreover, overexpression of KCNQ1 channels suppressed cell invasion of cultured human HCC cells, and pharmacological activation of KCNQ1 restrained tumor metastasis of HCC in nude mice."
30144972
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"By Transwell assay, we showed that overexpression of KCNQ1 significantly suppressed the invasion of Huh7 and LM3 cells ( Fig. 2 C)."
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"Overexpression of the K channel KCNQ1 traps β-catenin on the plasma membrane, induces an open cavity in the CRC sphere, and slows the invasion of CRC cells."
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"On the other hand, overexpression of KCNQ1 inhibited the invasion of HCC, and the same study revealed that pharmacological activation of KCNQ1 channels inhibited tumor metastasis of HCC in nude mice."
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"In the present study, succinate inhibited the expression of KCNQ1 by activating SGK1 and further enhanced cell growth and invasion of UECC."
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"miR-483–5p promoted EC cell proliferation, migration and invasion by silencing KCNQ1."
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"In esophageal squamous cell carcinoma (ESCC), miR-483e5p overexpression silences KCNQ1 promoting cell proliferation, migration, and invasion [78]."
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"Overexpression of KCNQ1 trapped beta-catenin at the plasma membrane, induced a patent lumen in CRC spheroids, and slowed CRC cell invasion."
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