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USP8 deubiquitinates RNF41. 3 / 5
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"We found that the carboxy terminal domain of Nrdp1 binds to the rhodanese domain of USP8, and that USP8 very efficiently deubiquitinates and stabilizes Nrdp1."
20868762
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"SNAIL1, a key regulator of dedifferentiation, is stabilized in esophageal squamous cell carcinoma, breast cancer cells, and lung carcinoma cells by set of DUBs including OTUB1, DUB3, and USP37, respectively.36 37 38 DUB3 has also been shown to deubiquitinate SLUG and TWIST, the other two essential regulators of dedifferentiation.39 Recent few reports provided information on direct impact of DUBs on β-cell physiology.40 CLEC16A-RNF41 and USP8 form a tripartite complex, wherein CLEC16A is an E3 ligase that ubiquitinates RNF41 and USP8 is the DUB that deubiquitinates RNF41."
37250303
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"USP8 deubiquitinates STAM, preventing its degradation by the proteasome [XREF_BIBR], and Nrdp1, an E3 required for the lysosomal degradation of EGFR family members ErbB3 and ErbB4 [XREF_BIBR]."
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