 
            IndraLab
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                                  "Results ( Fig. 3a , b ) indicated that neither overexpression or knockdown of CYLD changed the expression of cyclin D or CDK4 or 6 , but influenced the protein level of p18 and pRb , and increasing CYLD expression caused an elevation in p18 levels in a dose-dependent manner in all cell lines ( Fig. 3c ) ."