IndraLab

Statements


CYLD activates CDKN2C. 4 / 4
| 2 2

eidos
"Results ( Fig. 3a , b ) indicated that neither overexpression or knockdown of CYLD changed the expression of cyclin D or CDK4 or 6 , but influenced the protein level of p18 and pRb , and increasing CYLD expression caused an elevation in p18 levels in a dose-dependent manner in all cell lines ( Fig. 3c ) ."

reach
"Loss of CYLD causes the degradation of p18 and induces the G1/S transition."

eidos
"Loss of CYLD causes the degradation of p18 and induces the G1 / S transition ."

reach
"In contrast, knockdown of CYLD substantially decreased the half-life of p18."