IndraLab

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USP18 activates EGFR. 9 / 10
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"In addition, the results indicated that USP18 may promote the epidermal growth factor (EGF)-mediated EGF receptor (EGFR)/AKT/S-phase kinase associated protein2 (Skp2) pathway by upregulating EGFR and Skp2 in a AKT and forkhead boxO3 dependent manner in breast cancer."

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"However, USP18 has independent direct effects on tumor growth and survival and enhances EGFR signaling by decreasing miR-7 expression, which targets EGFR XREF_BIBR."

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"For instance, Tan et al. found that USP18 promotes breast cancer growth by upregulating EGFR and activating the AKT and Skp2 pathway [XREF_BIBR]."

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"USP18 promotes breast cancer growth by upregulating EGFR and activating the AKT and Skp2 pathway."

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"Moreover, USP18 competitively inhibits IFN-alpha and beta-induced JAK and STAT activation [XREF_BIBR] and upregulates epidermal growth factor receptor (EGFR) expression [XREF_BIBR]."

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"Inhibition of USP18 reduces the levels of EGFR and other oncogenic proteins and inhibits the tumorigenic activity of cancer cells."

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"In addition, the results indicated that USP18 may promote the epidermal growth factor (EGF)-mediated EGF receptor (EGFR)/AKT/S-phase kinase associated protein2 (Skp2) pathway by upregulating EGFR and Skp2 in a AKT and forkhead boxO3 dependent manner in breast cancer."

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"Tan et al. have demonstrated that USP18 promotes breast cancer growth by upregulating EGFR and activating the AKT and Skp2 pathway."

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"However, USP18 has independent direct effects on tumor growth and survival and enhances EGFR signaling by decreasing miR-7 expression, which targets EGFR [54]."