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OTUB1 binds FGFR2. 5 / 5
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"Deletion of the UBA domain disrupted the interaction between FGFR2 and OTUB1 (Fig. 3f), indicating that the interaction between OTUB1 and FGFR2 was dependent on the UBA domain of OTUB1, which is absent in OTUB2.The downregulated protein level of FGFR2 in OTUB1-deficient cells prompted us to test whether OTUB1 is a potential DUB for FGFR2."
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"Mechanistically, OTUB1 binds FGF receptor 2 (FGFR2) and decreases its ubiquitination through the non-canonical mechanism (Zhu et al., 2023)."
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"Co-immunoprecipitation assays indicated a specific interaction between OTUB1 and FGFR2, but not between the other nine examined members of the OTU family (Supplementary Fig. xref )."
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"It’s well known that OTUB1 contains two domains: the N-terminal ubiquitin-association (UBA) domain and the C-terminal ovarian tumor (OTU) domain. xref Deletion of the UBA domain disrupted the interaction between FGFR2 and OTUB1 (Fig. xref ), indicating that the interaction between OTUB1 and FGFR2 was dependent on the UBA domain of OTUB1, which is absent in OTUB2."
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