IndraLab

Statements

SETDB1 binds OTUD4. 6 / 6
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"However, in the absence of flag-tagged IRTKS, the interaction between OTUD4 and SETDB1 did not exist ( Fig. 4 D and E and S4E), suggesting that IRTKS acts as a scaffold protein to permit SETDB1 and OT[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Co-IP assay using SK-Hep-1 cell lysates confirmed that IRTKS was essential in the interaction among IRTKS, OTUD4, and SETDB1, where in the absence of IRTKS, both SETDB1 and OTUD4 did not interact, but[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Because the I-BAR domain mediates the interaction of both OTUD4 and SETDB1, we thus tested whether I-BAR deletion mutant can reverse the decreased H3K9me3 level and the increased SETDB1 ubiquitination[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, in the absence of flag-tagged IRTKS, the interaction between OTUD4 and SETDB1 did not exist ( Fig. 4 D and E and S4E), suggesting that IRTKS acts as a scaffold protein to permit SETDB1 and OT[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data suggest that IRTKS may affect the protein accumulation of SETDB1 through OTUD4 deubiquitinase activity.Because the I-BAR domain mediates the interaction of both OTUD4 and SETDB1, we thus te[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, the deubiquitylation of OTUD4 on SETDB1 is dependent on IRTKS that recruits the two proteins, a deubiquitinase and its substrate, for their enzymatic reaction via the same I-BAR domain;[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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