IndraLab

Statements

Acetylsalicylic acid inhibits IKBKB. 23 / 24
4 | 15 4
ctd
No evidence text available
10480951
reach
"It has been shown that aspirin, as well as sodium salicylate, inhibits IKK-beta activity in vitro at millimolar concentration [XREF_BIBR] by binding to IKK-beta, thus, competing with ATP for the binding to the kinase, an event necessary to phosphorylate IkB [XREF_BIBR, XREF_BIBR]."
24281340
reach
"Yin et al. have reported that aspirin inhibits the activity of IKKbeta, which is the essential kinase in the NF-kappaB activation pathway [4]."
24613833
reach
"XREF_BIBR High doses of aspirin have been shown to inhibit IKK-beta and might therefore ameliorate insulin resistance and improve glucose tolerance in at least some patients with T2D."
25120374
sparser
"Glibenclamide achieves antidiabetic activity by binding with sulfonylurea receptor 1 (SUR1), which inhibits the conductance of the adenosine triphosphate (ATP)-dependent potassium (K ATP ) channel whereas aspirin inhibits the serine kinase IKKβ [ xref ]."
25775424
reach
"Aspirin inhibits certain enzymes (I-kappa-B-kinase-beta (IKK-beta)) an enzyme important in the cascade of signals that activate the nuclear factor NF-kappaB family of genes which regulate certain infl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12946657
reach
"High-dose aspirin inhibits cyclooxygenase and IkappaB kinase-beta and reduces fasting plasma glucose concentration, although there has not, as yet, been a large-scale trial to examine the effect of aspirin on the risk of developing diabetes."
16472047
ctd
No evidence text available
15861417
sparser
"There is evidence that aspirin, which was shown to block NF-κB activation [183 , 184] , directly binds and inhibits IKKβ [185] ."
12507553
reach
"Lastly, direct inhibition of IKKbeta by aspirin, salicylate, and sulindac may be another mechanism that could account for the antiproliferative effects of these NSAIDs via downregulation of NF-kappaB-mediated proliferative genes such as interleukin-2 (IL-2), granulocyte-macrophage colony stimulating factor (GM-CSF), c-myc, cyclin D1, and COX-2, among others."
23875171
reach
"At a higher concentration, both nonacetylated salicylates and aspirin are known to inhibit the IKKbeta and NF-kappaB axis, an important regulator of inflammation [XREF_BIBR, XREF_BIBR]."
28042580
sparser
"Lastly, direct inhibition of IKKβ by aspirin, salicylate, and sulindac may be another mechanism that could account for the antiproliferative effects of these NSAIDs via downregulation of NF-κB-mediated proliferative genes such as interleukin-2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF), c-myc, cyclin D1, and COX-2, among others."
23875171
reach
"Sulindac [75], aspirin and salicylate [76] specifically inhibit IkKB kinase activity, and sanguinarine has also been shown to inhibit NFkB activation at the level of IkB phosphorylation [77]."
12419552
reach
"The use of the IKKbeta blocker aspirin or of other salicylates had a markedly positive effect on insulin resistance in patients with TD2M as well as in insulin resistant mouse models [XREF_BIBR]."
24897026
reach
"Yin et al. have reported that aspirin is the specific inhibitor of IKKbeta, which is the essential kinase for NF-kappaB activation [4]."
24613833
ctd
No evidence text available
16472047
reach
"The IKK inhibitors parthenolide and aspirin blocked the activities of infection induced IKKalpha and IKKbeta, leading to attenuation of nuclear translocation of NF-kappaB."
15618150
reach
"Previous reports indicated that aspirin specifically inhibits IKKbeta activity, and constitutively active form of IKKbeta accelerates APC loss."
24613833
sparser
"Aspirin, salicylate, and sulindac can directly bind and inhibit recombinant IKKβ, the upstream positive regulator of NF-κB ( xref )."
23875171
ctd
No evidence text available
16199534
reach
"Here we demonstrate that the anti-inflammatory agents aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo."
9817203
reach
"Recently, sodium salicylate and aspirin have been shown to inhibit activation of the transcription factor NF-kappaB by preventing IKK-beta from degradation."
25120374
reach
"Whereas sulfasalazine was found to inhibit both IKKalpha and IKKbeta, aspirin and sodium salicylate were reported to specifically inhibit IKKbeta."
12110242