IndraLab

Statements

Acetylsalicylic acid inhibits IKBKB. 26 / 37
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"Recently, sodium salicylate and aspirin have been shown to inhibit activation of the transcription factor NF-kappaB by preventing IKK-beta from degradation."
25120374
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"Aspirin inhibits the activity of IKK-b; however, it also causes asthma exacerbation by separate mechanisms in a subset of aspirin sensitive asthmatics."
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"Here we demonstrate that the anti-inflammatory agents aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo."
9817203
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"XREF_BIBR High doses of aspirin have been shown to inhibit IKK-beta and might therefore ameliorate insulin resistance and improve glucose tolerance in at least some patients with T2D."
25120374
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"YIN M J, Y AMAMO T O Y, G A Y N O R R B : T h e anti-inflammatory agents aspirin and salicylate inhibit the activity of IkappaB kinase-beta."
11336564
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"Lastly, direct inhibition of IKKbeta by aspirin, salicylate, and sulindac may be another mechanism that could account for the antiproliferative effects of these NSAIDs via downregulation of NF-kappaB-mediated proliferative genes such as interleukin-2 (IL-2), granulocyte-macrophage colony stimulating factor (GM-CSF), c-myc, cyclin D1, and COX-2, among others."
23875171
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"Aspirin inhibits certain enzymes (I-kappa-B-kinase-beta (IKK-beta)) an enzyme important in the cascade of signals that activate the nuclear factor NF-kappaB family of genes which regulate certain infl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12946657
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"High-dose aspirin inhibits cyclooxygenase and IkappaB kinase-beta and reduces fasting plasma glucose concentration, although there has not, as yet, been a large-scale trial to examine the effect of aspirin on the risk of developing diabetes."
16472047
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"YIN MJ, YAMAMOTO Y, GAYNOR RB : The anti-inflammatory agents aspirin and salicylate inhibit the activity of IkappaB kinase-beta."
17227230
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"At a higher concentration, both nonacetylated salicylates and aspirin are known to inhibit the IKKbeta and NF-kappaB axis, an important regulator of inflammation [XREF_BIBR, XREF_BIBR]."
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"Likewise, treating obese and insulin resistant rodents with the anti-inflammatory compound Aspirin demonstrated that inhibition of the inflammatory kinase IKKβ by Aspirin resulted in improved insulin [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25583116
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"Aspirin, salicylate, and sulindac can directly bind and inhibit recombinant IKKβ, the upstream positive regulator of NF-κB ( xref )."
23875171
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"Several anti-inflammatory drugs have been shown to inhibit NF-κB activation at different stages: aspirin and salicylate specifically inhibit IKK-2 activity ( Yin et al., 1998 ), while corticosteroids [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15464079
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"It has been shown that aspirin, as well as sodium salicylate, inhibits IKK-beta activity in vitro at millimolar concentration [XREF_BIBR] by binding to IKK-beta, thus, competing with ATP for the binding to the kinase, an event necessary to phosphorylate IkB [XREF_BIBR, XREF_BIBR]."
24281340
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"YIN MJ, YAMAMOTO Y, GAYNOR RB : The anti-inflammatory agents aspirin and salicylate inhibit the activity of IkappaB kinase-beta."
17227228
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"Glibenclamide achieves antidiabetic activity by binding with sulfonylurea receptor 1 (SUR1), which inhibits the conductance of the adenosine triphosphate (ATP)-dependent potassium (K ATP ) channel whereas aspirin inhibits the serine kinase IKKβ [ xref ]."
25775424
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"Aspirin inhibits IKK-β and prevents the nuclear factor-κB (NF-κB) dependent expression of pro-inflammatory genes [92] ."
25194174
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"The IKK inhibitors parthenolide and aspirin blocked the activities of infection induced IKKalpha and IKKbeta, leading to attenuation of nuclear translocation of NF-kappaB."
15618150
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"Lastly, direct inhibition of IKKβ by aspirin, salicylate, and sulindac may be another mechanism that could account for the antiproliferative effects of these NSAIDs via downregulation of NF-κB-mediated proliferative genes such as interleukin-2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF), c-myc, cyclin D1, and COX-2, among others."
23875171
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"YIN M, Y AMAMO T O Y, G A Y N O R R B : T h e anti-inflammatory agents aspirin and salicylate inhibit the activity of IkappaB kinase-beta."
15992176
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"Whereas sulfasalazine was found to inhibit both IKKalpha and IKKbeta, aspirin and sodium salicylate were reported to specifically inhibit IKKbeta."
12110242
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"The use of the IKKbeta blocker aspirin or of other salicylates had a markedly positive effect on insulin resistance in patients with TD2M as well as in insulin resistant mouse models [XREF_BIBR]."
24897026
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"There is evidence that aspirin, which was shown to block NF-κB activation [183 , 184] , directly binds and inhibits IKKβ [185] ."
12507553
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"Yin et al. have reported that aspirin is the specific inhibitor of IKKbeta, which is the essential kinase for NF-kappaB activation [4]."
24613833
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"Sulindac [75], aspirin and salicylate [76] specifically inhibit IkKB kinase activity, and sanguinarine has also been shown to inhibit NFkB activation at the level of IkB phosphorylation [77]."
12419552
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"Yin et al. have reported that aspirin inhibits the activity of IKKbeta, which is the essential kinase in the NF-kappaB activation pathway [4]."
24613833