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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNQ2 inhibits potassium(1+). 2 / 2

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"In response to muscarinic agonists, PKC phosphorylates the KCNQ2 subunit and inhibits potassium current through the M channel, an important step in regulating neuronal excitability."

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"Muscarinic agonists such as acetylcholine mobilize an anchored pool of PKC that phosphorylates the KCNQ2 subunit of the M channel on Ser 541 to decrease potassium permeability."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...