IndraLab

Statements

USP18 binds SOX9. 12 / 12
3 | 1 8
biogrid
No evidence text available
33694203
biogrid
No evidence text available
33694203
biogrid
No evidence text available
33694203
sparser
"Further confirmation through coimmunoprecipitation experiments provided additional evidence of a physical interaction between USP18 and SOX9."
40374599
sparser
"To our knowledge, this study represents the first comprehensive investigation of the interaction between USP18 and the oncogenic transcription factor SOX9 in gliomas."
40374599
sparser
"Through its USP domain, USP18 interacts with SOX9, stabilising the protein and thereby promoting the maintenance of glioblastoma stemness and the progression of malignant phenotypes."
40374599
sparser
"Next, we examined whether the USP18 protein directly interacts with the SOX9 protein in cells."
40374599
sparser
"For example, USP18 could bind, deubiquitinate, and stabilize SOX9 protein, thereby positively regulating reactive astrogliosis [ xref ]."
41159065
sparser
"USP18 directly interacts with SOX9 and increases the stability of SOX9 in glioma cells."
40374599
sparser
"Endogenous USP18 and SOX9 proteins were coimmunoprecipitated from lysates of two GBM cell types, confirming a direct interaction between the USP18 and SOX9 proteins (Fig. xref )."
40374599
sparser
"Overall, these results indicate that USP18 and SOX9 physically interact through specific regions and that USP18 promotes SOX9 protein stability via the ubiquitin‒proteasome pathway."
40374599
reach
"We showed that USP18 binds, deubiquitinates, and thus, stabilizes SRY-box transcription factor 9 (SOX9), thereby regulating reactive astrogliosis."
33694203