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Vemurafenib activates USP28. 2 / 2

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"It is important to note that in both cell lines tested vemurafenib treatment enhanced the expression USP28, indicative of a USP28 feedback loop in both these BRAF mutant cell lines (XREF_FIG)."

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"Pharmacodynamics studies demonstrated that depletion of USP28 led to a robust retention of ERK phosphorylation in tumors treated with vemurafenib (XREF_FIG)."

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Vemurafenib activates USP28. 2 / 2

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