Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Vemurafenib activates USP28. 2 / 2

| 2

➶

reach

"It is important to note that in both cell lines tested vemurafenib treatment enhanced the expression USP28, indicative of a USP28 feedback loop in both these BRAF mutant cell lines (XREF_FIG)."

29880484

➶

reach

"Pharmacodynamics studies demonstrated that depletion of USP28 led to a robust retention of ERK phosphorylation in tumors treated with vemurafenib (XREF_FIG)."

29880484

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...