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USP18 activates ZAP70. 1 / 1

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"Because USP18 deficiency potentiated activation of molecules such as IKK, JNK, and NFAT distal from TCR, but not TCR proximal signaling complex ZAP70 or PLC-gamma, we reasoned that USP18 might target some key molecules in between the proximal and distal signaling complexes, of which TAK1 is a promising candidate."

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USP18 activates ZAP70. 1 / 1

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