IndraLab

Statements

USP15 decreases the amount of BMP. 4 / 4
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"Depletion of USP15 reduces BMP induced phosphorylation of SMAD1 and the transcription of BMP-target genes, as well as inhibiting the differentiation of myoblasts into osteoblasts."
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"Consistent with this, pretreatment of HEK293 cells with the proteasomal inhibitor bortezomib does indeed rescue BMP induced pSMAD1 levels reduced by USP15 depletion (XREF_FIG b)."
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"RNAi mediated depletion of USP15 increases ALK3 K48 linked polyubiquitylation, and reduces both BMP induced SMAD1 phosphorylation and transcription of BMP target genes."
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"They also showed that depletion of USP15 in Hela cells increased polyubiquitynation of BMP type I receptor, and inhibited BMP mediated Smad1 phosphorylation and BMP target gene transcription."
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