IndraLab

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USP18 activates GSDMD. 3 / 3
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"Cycloheximide (CHX) chase assay further showed that USP18 deficiency also impaired the degradation rate of GSDMD (Fig. S2A and B and Fig. 2D and E)."
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"USP18 down-regulates the protein abundance of GSDMD, thereby inhibiting the activation of GSDMD and pyroptosis (Fig. 7)."
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"Taken together, these findings strongly indicate that USP18 enhances the recognition of GSDMD by multiple cargo receptors, thereby promoting its subsequent autophagic degradation."
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