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Sulfonylureas inhibits NLRP3. 3 / 3
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"We report the synthesis and biological evaluation of nine sulfonylureas that inhibit NLRP3 activation in murine bone-marrow- derived macrophages in a potent, dose dependent manner."
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"Nine different sulfonylureas have been reported to inhibit the activation of NLRP3 in mouse bone marrow-derived macrophages in a dose-dependent manner."
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"External use of sulfonylureas (such as Glibenclamide) can inhibit the activation of NLRP3, up-regulate IL-10, IGF-1 and TGF-β, down-regulate IL-1β, IL-18, and TNF-α, and as a result down-regulate the pro-inflammatory M1 phenotype, up-regulate the pro-healing M2 phenotype and promote wound healing in DM mice (Mirza et al., 2014)."
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