IndraLab

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OTUD6B activates type I interferon production. 3 / 3
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"It was shown that IFN-β reporter luciferase activity was no longer enhanced by overexpressing IRF3/5D in the presence of OTUD6B (Fig. 4A), suggesting that OTUD6B might promote type I IFN production via IRF3."
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"Furthermore, we demonstrated that OTUD6B can promote type I IFN production and cellular antiviral responses in vivo, which may provide a potential target for enhancing type I IFN antiviral therapy in clinical settings."
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"OTUD6B promoted type I IFN production in response to viral infection."
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