IndraLab

Statements

ATP inhibits DDX58. 2 / 3
| 2
reach
"Mutation of the RIG-I ATP binding site abolishes RIG-I activity, suggesting that ATP and RNA dependent conformational changes are essential for sensing viral RNA XREF_BIBR."
19115016
reach
"It was reported that RIG-I ATP hydrolysis increases the binding affinity of RIG-I and dsRNA ligands; whereas the RIG-I mutants deficient in ATP hydrolysis promotes the interaction of RIG-I and self-dsRNA and results in unintentional immune signaling (47)."
28096803