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USP4 activates Neoplasm Invasiveness. 41 / 41
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"USP4 promotes the migration and invasion of lung adenocarcinoma cells by regulating cellular EMT processes."
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"Collectively, these data demonstrated that USP4 promotes melanoma cell migration and invasion by promoting EMT."
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"Transwell assays showed that USP4 knockdown inhibited cell migration and invasion in MHCC97H and LM3 cells."
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"Moreover, USP4 upregulation promoted Huh7 and PLC/PRF/5 cell migration and invasion ability (P < 0.01 for all)."
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"Transwell invasion assay further confirmed USP4 expression significantly accelerated invasion ( Fig. 5 A and B)."
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"In summary, these data indicate that USP4 enhances HCC cell proliferation, migration, and invasion and suppresses HCC cell apoptosis in vitro."
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"By promoting activation of the relaxin and TGF-beta 1/Smad2/matrix metalloproteinase 9 axis and transcriptional repression activity of HDAC2, USP4 induces breast cell invasion, migration, and proliferation both in vitro and in vivo."
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"Further experiments found that overexpression of USP4 could significantly enhance the migration and invasion of CRC and promote the expression of stemness-related genes such as SOX9, OCT4, and CD133."
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"Decreased level of USP4 protein leads to increased ubiquitination of ELAV-like RNA-binding protein 1 (ELAVL1), which in turn increases Rho GDP dissociation inhibitor alpha (ARHGDIA) expression, ultimately promoting migration and invasion of PCa cell.23 METTL3 was also found to affect lymphoid enhancer-binding factor 1 (LEF1) protein levels by affecting m A methylation of LEF1 mRNA, thereby downregulating the activity of wingless/integrated (Wnt) signaling to affect PCa progression."
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"USP4 accelerates the growth, invasion, and metastasis of colorectal cancer [XREF_BIBR, XREF_BIBR]."
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"The migration and invasion assays showed that USP4 promotes human breast cancer cell migration and invasion by USP4 overexpression, and knockdown of USP4 by siRNA inhibits human breast cancer cell migration and invasion."
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"As we have discussed above, USP4 can target the TGF-beta type I receptor and promote invasion and metastasis of breast cancer and high USP15 expression correlated with enhanced pSmad2 expression in ti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP4 expression is upregulated in CRC and shown to promote tumor cell migration and invasion."
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"Data showed in Fig. 1D and E demonstrated that overexpression of USP4 significantly promoted CRC migration and invasion."
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"USP4 promotes invasion of breast cancer cells via Relaxin and TGF-beta 1/Smad2/MMP -9 signal."
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"Using in vitro and in vivo assays, we demonstrated that USP4 overexpression enhanced HCC cell growth, migration, and invasion."
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"Functionally, the upregulation of USP4 in CRC cells significantly promoted CRC migration and invasion (Fig. 1D and E)."
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"Inhibition of USP4 would be expected to inhibit the invasion and metastasis of breast cancer and drugs that target USP15 could reduce the oncogenic potential of glioblastomas."
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"Moreover, we observed that the invasion activity of HCT116 cells was suppressed by USP4 knockdown."
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"USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1."
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"Loss- and gain-of-function assays suggested that USP4 silencing inhibited ESCC cell proliferation, migration, and invasion, while USP4 overexpression promoted these behaviors."
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"The reduction in USP4 expression decreases the level of ELAVL1 protein deubiquitination, leading to decreased ELAVL1 protein expression and increased ARHGDIA expression, promoting bladder cancer cell migration and invasion [98]."
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"USP4 overexpression increased the migration and invasion abilities of breast cancer cells in vitro ."
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"Importantly, USP4 promotes ESCC proliferation, migration, and invasion via the MEK/ERK signaling pathway and can be inhibited by U0126."
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"Studies have shown that USP4 plays an important role in rectal cancer bladder cancer melanoma The high expression of USP4 in liver cancer and cervical squamous cell carcinoma implies that USP4 may be a potential oncogene, and it has been confirmed that the abnormal expression of USP4 promotes the occurrence, development, invasion and metastasis of rectal cancer ."
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"In addition, USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1."
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"Using gene interference, we demonstrated that USP4 knockdown significantly inhibited HCC cell migration and invasion in vitro, and USP4 overexpression had the opposite results."
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"USP4 promotes ESCC cell migration and invasion."
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"Similar results were obtained from Transwell assays, which also suggested that cell invasion was markedly attenuated by USP4 silencing in KYSE150 cells but was increased by USP4 overexpression in KYSE180 cells (Fig. 3C, D)."
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"Collectively, these data suggest that USP4 significantly promotes ESCC cell migration and invasion in vitro and metastasis in vivo."
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"Conversely, the function of USP4 in promoting the proliferation, migration, and invasion abilities of KYSE180 cells was largely reversed by the knockdown of TAK1 (Supplementary Fig. 2A-C)."
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"USP4 accelerates HCC cell proliferation, migration, and invasion in vitro."
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"USP4 can promote the migration and invasion of lung adenocarcinoma cells."
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"Taken together, our results elucidate that USP4 is highly expressed in HCC and promotes the tumor invasion and metastasis, the underlying mechanism is that USP4 directly interacts with and deubiquitinates TGFR-1 to increase TGF-beta signaling Induced EMT."
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"Subsequently , Cao et al. further confirmed that USP4 can promote cell migration and invasion through relaxin / TGF-beta1 / smad2 / matrix metalloprotein-9 signaling pathway [ 92 ] ."
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"USP15 and USP4 promote cell proliferation and invasion in lung cancer cell lines."
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"Our study showed that after interfering with USP4 expression, lung adenocarcinoma cells changed from a long spindle shape to round, the migration and invasion abilities of cells decreased, N-cadherin expression decreased, and E-cadherin expression increased, indicating that USP4 promoted the invasion and migration of lung adenocarcinoma cells by promoting the EMT of cancer cells."
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"In contrast, depletion of USP4 significantly inhibited proliferation, migration, and invasion abilities in vitro and suppressed tumor growth and metastasis in vivo."
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"USP4 can promote TGF-beta-induced invasion and metastasis of breast cancer cells in a zebrafish xenograft model."
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"3.4 USP4 up-regulation contributes to melanoma invasion and migration by promoting EMT."
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"On the other hand, SRSF1 is upregulated by high USP15 and USP4 that enhance cell proliferation and invasion (Fig. 7D)."
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