IndraLab

Statements

USP9X deubiquitinates XIAP. 4 / 4
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"We reasoned that USP9X deubiquitylates XIAP to regulate mitotic survival."
27317434
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"These studies revealed a mitosis specific function for the ubiquitin specific protease 9X (USP9X), which we show to deubiquitylate and stabilize XIAP in order to promote mitotic survival."
27317434
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"69 USP9X also can induce deubiquitylation and stabilization of XIAP, resulting in increased resistance toward MTAs in aggressive B‐cell lymphoma."
36967563
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"Engel et al. [XREF_BIBR] demonstrate that USP9X is the mitotic deubiquitinase of the X linked inhibitor of apoptosis protein (XIAP) and that deubiquitylation and stabilization of XIAP by USP9X lead to increased resistance toward mitotic spindle poisons."
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