IndraLab

Statements

UCHL1 activates CSF2. 5 / 5
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"Ubiquitin C-Terminal Hydrolase L1 (UCHL1) was elevated in the CSF of all symptomatic groups as compared to non-carrier controls (S-NC: 117.4%, P=0.044; S-GRN: 142.6%, P<0.001; S-C9orf72: 123.5%, P=0.015; S-MAPT: 126.7%, P=0.005; Fig. 4C)."
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"UCHL1 was also elevated in CSF in comparisons of all other symptomatic groups with age matched non‐carrier controls (sporadic ALS log fold change 0.53, FDR‐adjusted p‐value <0.001; C9orf72 ALS log fold change 0.51, FDR‐adjusted p‐value <0.001; sporadic FTD log fold change 0.41, FDR‐adjusted p‐value = 0.007; C9orf72 FTD log fold change 0.31, FDR‐adjusted p‐value = 0.010) (Fig S2)."
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"First investigated in patients with severe TBI, UCH-L1 significantly increases in the CSF and serum within the first 24 hr of injury, followed by a rapid decline over the following 7 days."
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"However, due to the semi-quantitative and less sensitive nature of Western blot, it does not detect low levels of UCH-L1 increase in CSF as well as the ELISA is capable."
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"Concentrations of UCH-L1 protein increase in human blood and CSF after a wide range of diseases or conditions leading to brain damage like subarachnoid hemorrage, traumatic brain injury, and epileptic seizure, carbon monoxide poisoning and neonatal hypoxic-ischemic encephalopathy."
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