IndraLab

Statements

USP9X activates XIAP. 4 / 6
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"In this analysis, USP9X and XIAP double high cases were compared to the remaining cases (including cases with low USP9X and high XIAP) because these cases reflect the constellation where elevated XIAP is predicted to result from mitotic USP9X mediated stabilization of XIAP."
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"First, we investigated the role of USP9X mediated stabilization of XIAP in the context of B-cell lymphoma maintenance invivo."
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"In aggressive B cell lymphoma, USP9X decreased the degradation of X linked inhibitor of apoptosis protein (XIAP) to confer resistance against spindle poison containing chemotherapy [XREF_BIBR]."
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"In addition, loss of USP9X caused a substantial reduction in the protein expression of c-Myc and XIAP, whereas the protein levels of GAPDH and beta-actin (DeltaG 5 ' UTR = -16 kcal and mol), whose 5 ' UTR are relatively unstructured, remained unchanged."
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