IndraLab

Statements

USP7 inhibits E3_Ub_ligase. 6 / 6
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"Indeed, HAUSP was shown to reduce the E3 ligase activity (autoubiquitination) of wild-type UHRF1 but not in the UHRF1 K659E mutant, disturbing the UHRF1 domain involved in its interaction with HAUSP [XREF_BIBR]."
27839516
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"Depletion of USP7 impairs mitotic progression, stabilizes cyclin B and reduces stability of the mitotic E3 Ub ligase, checkpoint with forkhead and Ring-finger (CHFR)."
23348568
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"For instance, the inhibition of ubiquitin-specific protease 7 (USP7) results in the degradation of the oncogenic E3 ligase Mouse double minute 2 homolog (MDM2) and leads to re-activation of the tumor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30905413
eidos
"Next , the E3 ubiquitin ligase activity of UHRF1 is hypothesized to be directly decreased by USP7 ."
35005106
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"Second, we hypothesize that HAUSP directly inhibits the E3 ubiquitin ligase activity of UHRF1."
21045206
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"Next, the E3 ubiquitin ligase activity of UHRF1 is hypothesized to be directly decreased by USP7."
35005106