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Bedaquiline inhibits KCNH2. 3 / 3

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"Both bedaquiline and M2 inhibit the cardiac hERG and IKr potassium channels in vitro, 30 and modest QT prolongation has been observed during clinical trials."

25535219

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"The M2 bedaquiline metabolite inhibits KCNH2 (hERG), interfering with potassium channel function and consequently interfering with normal cardiac repolarization and prolonging the QT interval [156]."

36479687

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"Bedaquiline itself (1) is a potent inhibitor of the hERG potassium channel (IC 1.6 "

29482950

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Bedaquiline inhibits KCNH2. 3 / 3

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