IndraLab

Statements

L-ascorbic acid inhibits NLRP3. 5 / 5
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"Indeed, vitamin C, vitamin D, and omega-3 fatty acids have all been shown to inhibit the NLRP3 inflammasome and may work synergistically against the cytokine storm associated with COVID-19 and specifically against the neuro inflammation associated with its delirium."
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"* Vitamin C : Like flavonoids, ascorbic acid inhibits NLRP3 inflammasome activation."
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"On the other hand, resveratrol and vitamin C have been shown to reduce ROS production and NLRP3 inflammasome activity in mouse lung tissue and macrophages, respectively [XREF_BIBR, XREF_BIBR]."
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"However, most recent studies also suggest another important role of ascorbic acid in the reduction of urate induced inflammation by inhibiting activation of responsible NLRP3 inflammasomes."
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"The results of this study showed that quercetin and ascorbic acid owing to their antioxidant properties can prevent the activation of NLRP3 inflammasome through TXNIP and thus prevent the exacerbation of inflammation [XREF_BIBR]."
| PMC