IndraLab

Statements


TP53 increases the amount of OTUD5. 2 / 2
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"P53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer."

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"Collectively, these findings elucidate a mechanism whereby p53 inactivation upregulates OTUD5 transcription to deubiquitylate and stablize GPX4, resulting in ferroptosis inhibition and gastric cancer progression."