IndraLab

Statements

Arg-Val inhibits STAT1. 6 / 6
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"RV has also been shown to inhibit the function of STAT1 and STAT2 by an unknown mechanism and thus, can potentially inhibit all types of IFN responses [XREF_BIBR]."
22677178
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"Interestingly, we found that TLR2 reduces RV induced STAT1 and STAT2 activation indicating TLR2 may inhibit amplification of IFNs that involves JAK and STAT signaling pathway."
31548332
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"Furthermore, RV infection was observed to block the migration of STAT1, STAT2 and NF-kappaB to the nucleus, thus preventing host cell immune responses [XREF_BIBR]."
29231855
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"Although viral factors responsible for this inhibitory effect downstream of STAT1 activation have not yet been identified, it is possible that redundancy in RV inhibition of the STAT1 pathway exists, perhaps indicative of the vital role of inhibiting IFN signaling in enabling RV replication.The ability of the RV NSP1 protein to target IRFs for proteasomal degradation extends to IRF7 and IRF9, two additional factors that are critical for the optimal amplification of IFN-dependent antiviral responses [40], [42]."
| PMC
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"In contrast, RV inhibition of IFNdirected STAT1 activation in RV-infected cells is well characterized [26, 52, 67] ."
| PMC
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"In these situations, discovering novel therapeutic modalities that can dampen IFN signaling is potentially valuable.Other RV strategies have also been identified that are directed at disrupting STAT1 signaling during infection."
| PMC