IndraLab

Statements

USP27X increases the amount of CBX2. 4 / 4
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"One of the key findings in our study is that overexpression of USP27X significantly enhances the level of CBX2 through deubiquitination."
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"The results showed that USP27X knockdown increased endogenous CBX2 ubiquitination, while USP27X overexpression decreased CBX2 ubiquitination levels (Fig. 3A, B)."
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"As expected, treatment with the proteasome inhibitor MG132 effectively restored the decreased levels of CBX2 induced by USP27X knockdown, while inhibition of autophagy-lysosomal pathway with CQ failed to exhibit such a restorative effect (Fig. 2F)."
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"Overexpression of USP27X significantly enhances CBX2 levels by promoting deubiquitination, while deficiency of USP27X leads to CBX2 degradation, thereby inhibiting tumorigenesis."
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