IndraLab

Statements

Malignant Mesothelioma binds BAP1. 4 / 4
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"The demonstration that BAP1 mutations are strongly associated with MM has provided a real breakthrough in the study of genetic predisposition in MM, that may explain why only a fraction of asbestos-exposed individuals go on to develop MM."
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"BAP1 knockdown in MM cell lines has been paradoxically associated to a decreased proliferation, with an accumulation of cells in the S phase of the cell cycle xref , suggesting that BAP1 loss might promote tumorigenesis inducing a delayed, but more permissive, G1/S checkpoint xref ."
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"Here, we tested the hypothesis that MM associated with germline BAP1 mutations has a better prognosis compared with sporadic MM."
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"The association of germline BAP1 mutations with familial MM has been confirmed in a series of recent reports ( xref - xref )."
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