IndraLab
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Costunolide inhibits NFKB1. 1 / 1
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"Although, the costunolide is a major telomerase inhibitor, it is also known to the drop the intracellular glutathione (GSH) and consequently inhibits tyrosine phosphorylation of STAT3 in HepG2 and C3A [XREF_BIBR]; In addition, costunolide inhibits c-Fos and NF-kb, both related to PI3k/Akt/mTOR signaling pathway modulation; This could explain the additional effect of this molecule shown in this study."