IndraLab

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OTUD3 inhibits OTUD3. 6 / 6
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"To further confirm that OTUDin3 is an inhibitor of OTUD3, we first performed surface plasma resonance (SRP) assays."
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"This implied that OTUDin3 bound to OTUD3 with a certain specificity.Next, we performed in vitro deubiquitination assays to verify whether OTUDin3 inhibits the deubiquitinating activity of OTUD3."
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"The results indicated that OTUDin3 inhibited the deubiquitinating activity of OTUD3 to cleave K48- and K63- linked diUb (Fig. 1K, Supplementary Fig. 1F)."
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"CHIP interacts with, polyubiquitylates OTUD3 and promotes OTUD3 degradation."
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"OTUDin3 enhanced degradation of the substrate GRP78 by inhibiting the deubiquitinating activity of OTUD3."
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"OTUDin3 downregulates GRP78 by inhibiting the deubiquitinating activity of OTUD3."
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