IndraLab

Statements


Spautin-1 decreases the amount of USP13. 3 / 3
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"In addition, spautin-1 also downregulated the expression of USP10 and USP13 at the protein level [53]."

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"Cerebral I/R significantly reduced the expressions of NLRP3, USP13, beclin 1, and GSDMD-N, which was abolished by spautin-1, indicating that spautin-1 inhibited autophagy and NLRP3 inflammasome-mediated pyroptosis."

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"Interestingly, the treatment of spautin-1 also reduced the levels of USP10 and USP13, but not USP14, a DUB involved in regulating proteasome function, or Rubicon, a negative regulator of type III PI3 kinase (XREF_FIG)."