
IndraLab
Statements
Hyaluronic acid binds SPP1 and CD44. 2 / 2
|
2
sparser
"Because the interactions between CD44 and its ligands, HA and OPN, have been shown to upregulate osteoclast differentiation and function, in addition to the cell-cell interactions mediated by RANK and RANKL, the cell-matrix interactions mediated by these molecules may also contribute to the progression of osteoclastic bone destruction."