IndraLab
Statements
Hyaluronic acid binds SPP1 and CD44. 4 / 4
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4
sparser
"Because the interactions between CD44 and its ligands, HA and OPN, have been shown to upregulate osteoclast differentiation and function, in addition to the cell-cell interactions mediated by RANK and RANKL, the cell-matrix interactions mediated by these molecules may also contribute to the progression of osteoclastic bone destruction."