IndraLab

Statements

USP8 is phosphorylated. 9 / 9
| 9
rlimsp
"Activation of RTKs by growth factors phosphorylates USP8, which suppresses the degradation of trichoplein and causes phosphorylation and activation of AurA, resulting in the suppression of ciliogenesis."
30643718
rlimsp
"This phosphorylation-mediated regulation of USP8 is present during the interphase, while during the M phase USP8 is dephosphorylated [72]."
21480003
rlimsp
"Since decreased USP8 tyrosine phosphorylation is associated with enhanced endosomal recycling of EGFR when cells are stimulated by TGFα, it is likely that USP8 phosphorylation may regulate its DUB activity."
23902637
rlimsp
"Role of Phosphorylation Events in the Activity and Stability of USP8."
21480003
rlimsp
"We then analyzed the roles of EGFR-mediated phosphorylation of USP8 in ciliogenesis."
29472535
rlimsp
"Meanwhile, treatment with lysophosphatidic acid, the major mitogen in serum, disassembled cilia sufficiently, despite with the relatively low, but significant, phosphorylation levels of EGFR and USP8."
29472535
rlimsp
"Here, we focused on epidermal growth factor receptor (EGFR) kinase because it has been reported to bind and phosphorylate USP8."
29472535
rlimsp
"Remarkably, 14-3-3 protein interactions that depend on phosphorylation of the 14-3-3BM in USP8 were shown to inhibit USP8 activity in vitro and in vivo [18]."
31845722
rlimsp
"A) EGF activates USP8 through phosphorylation."
31611503