IndraLab

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"A20 inhibits in vivo NPC cell growth."

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"The deletions or mutations of TNFAIP3 are found in about 30% of patients with diffuse large B-cell lymphoma, while reinforced TNFAIP3 induces apoptosis and cell growth arrest XREF_BIBR, suggesting TNFAIP3 is a tumor suppressor."

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"Our data also showed that in both 2D culture and 3D mammosphere growth assays, activation of the iFGFR1 signaling increased the growth of DCIS-iFGFR1 cells, while KO of TNFAIP3 in these cells completely diminished the iFGFR1 signaling-induced cell growth."