IndraLab

Statements

Sulforaphane inhibits STAT1. 5 / 5
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"Instead, SFN inhibits IFN-gamma-mediated activation of STAT1, a key transcription factor involved in PD-L1 induction."
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"SFN inhibited IFN-gamma and TNF-alpha-induced NF-kappaB activation as well as STAT1 activation."
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"In addition, sulforaphane can also decrease STAT-1 and NLRP3 inflammasome activation by the Nrf2/HO-1 signaling pathway in human microglia-like THP-1 cells [161]."
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"qRT-PCR measurements further demonstrated that SFN markedly reduced the IFN-γ-induced upregulation of multiple downstream targets of STAT1, not limited to IRF1 (Fig. 4C)."
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"Collectively, our results indicate that SFN inhibits STAT1 activation upon IFN-γ treatment.2.5 SFN covalently modifies cysteine 155 and 174 on the STAT1 protein."
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