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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

PKC decreases the amount of SCN5A. 1 / 1

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"Moreover, they found that PKC activation acutely decreases the surface expression of SCN5A and this effect is prevented by the NADPH oxidase inhibitor apocynin, suggesting that both channel phosphorylation and reactive oxygen species production are required for PKC mediated regulation of SCN5A trafficking."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...