IndraLab

Statements


HCN1 activates CA1. 3 / 3
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"This is in contrast to previous reports showing HCN1 downregulation in the pilocarpine model (Jung et al., 2007, 2010), but more recently, HCN1 immunoreactivity was found be increased, especially in CA1 interneurons (Oh et al., 2012)."

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"In addition, the transcriptional analysis revealed HCN1 upregulation and HCN3 downregulation in epileptic CA1."

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"The enhanced railroad-track pattern of the GFP-HCN1 signal in the CA1 apical dendrites is strongly suggestive of increased HCN1 channel expression in the dendritic surface membrane viewed in a confocal cross-section along the longitudinal axis of the dendrite (XREF_FIG, bottom right)."