IndraLab

Statements

JSH-23 inhibits RELA. 9 / 9
| 1 7 1
reach
"Co-immunofluorescence staining showed that SOCS1 expression was decreased while nuclear p65 was increased in the cancerous liver from Sptbn1 +/- mice after treatment with DDC, and p65 inhibition by JSH-23 reversed these effects resulted from SPTBN1 suppression (XREF_SUPPLEMENTARY D), which was also demonstrated in PLC/PRF/5 cells (XREF_SUPPLEMENTARY)."
33754058
reach
"We also found that NF-kappaB p65 promoted by sepsis was blocked by SST or/and JSH-23 (XREF_FIG, P < 0.05)."
33376482
reach
"IF staining showed that JSH-23 strongly prevented p65 from entering the nucleus in 109-T15 and 9706-T15 cells, whereas few changes were observed in cells treated with DMSO."
29650964
eidos
"Co-immunofluorescence staining showed that SOCS1 expression was decreased while nuclear p65 was increased in the cancerous liver from Sptbn1 + / - mice after treatment with DDC , and p65 inhibition by JSH-23 reversed these effects resulted from SPTBN1 suppression ( Figure S5D ) , which was also demonstrated in PLC / PRF / 5 cells ( Figure S2 ) ."
33754058
reach
"JSH-23 directly blocks the nuclear localization signal of p65 preventing its accumulation and localization in the nucleus."
27831553
sparser
"To confirm the regulatory relationship between EPHB4 and NF-κB, we used the inhibitor JSH-23 to inhibit NF-κB p65 in EPHB4-overexpressing SCC9 and UM1 cells."
34539874
reach
"The nuclear factor-kappa B (NF-kappaB) p65 pathway was inhibited by JSH-23, and the results showed that treatment with JSH-23 inhibited M1 macrophage differentiation and alleviated cardiac injury in LPS treated IL-5-knockout mice."
33043521
reach
"In fact, immunofluorescent studies were conducted using anti-p65 antibodies, and inhibition assays using JSH-23 specific inhibitor of p65 subunit of NF-kappaB, a subunit implicated in the classical NF-kappaB pathway only."
24130501
reach
"But Gm4419 still worked when p65 was inhibited by the p65 specific inhibitor JSH-23."
28151474