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JSH-23 inhibits RELA. 15 / 15
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"IF staining showed that JSH-23 strongly prevented p65 from entering the nucleus in 109-T15 and 9706-T15 cells, whereas few changes were observed in cells treated with DMSO."
29650964
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"But Gm4419 still worked when p65 was inhibited by the p65 specific inhibitor JSH-23."
28151474
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"Co-immunofluorescence staining showed that SOCS1 expression was decreased while nuclear p65 was increased in the cancerous liver from Sptbn1 +/- mice after treatment with DDC, and p65 inhibition by JSH-23 reversed these effects resulted from SPTBN1 suppression (XREF_SUPPLEMENTARY D), which was also demonstrated in PLC/PRF/5 cells (XREF_SUPPLEMENTARY)."
33754058
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"All animal work was conducted under the approval of the Experimental Animal Ethics Committee of Nanjing University of Chinese Medicine, China.The C3aR antagonist SB290157 and, the p65 antagonist JSH-2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37084829
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"JSH-23 directly blocks the nuclear localization signal of p65 preventing its accumulation and localization in the nucleus."
27831553
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"We also found that NF-kappaB p65 promoted by sepsis was blocked by SST or/and JSH-23 (XREF_FIG, P < 0.05)."
33376482
sparser
"But Gm4419 still worked when p65 was inhibited by the p65-specific inhibitor JSH-23."
28151474
sparser
"But Gm4419 still worked when p65 was inhibited by the p65-specific inhibitor JSH-23."
28151474
eidos
"Co-immunofluorescence staining showed that SOCS1 expression was decreased while nuclear p65 was increased in the cancerous liver from Sptbn1 + / - mice after treatment with DDC , and p65 inhibition by JSH-23 reversed these effects resulted from SPTBN1 suppression ( Figure S5D ) , which was also demonstrated in PLC / PRF / 5 cells ( Figure S2 ) ."
33754058
sparser
"To confirm the regulatory relationship between EPHB4 and NF-κB, we used the inhibitor JSH-23 to inhibit NF-κB p65 in EPHB4-overexpressing SCC9 and UM1 cells."
34539874
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"JSH-23 and H89 are inhibitors of p65 and MSK-1."
28038358
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"The addition of JSH-23 successfully inhibited the localization of p65."
37189677
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"In fact, immunofluorescent studies were conducted using anti-p65 antibodies, and inhibition assays using JSH-23 specific inhibitor of p65 subunit of NF-kappaB, a subunit implicated in the classical NF-kappaB pathway only."
24130501
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"Treatment of JSH-23 compound to LPS-stimulated RAW 264.7 cells decreased nuclear content of NF-κB p65 in a dose-dependent manner, corresponding to 49 ± 4% inhibition at 3 μM, 75 ± 7% at 10 μM and 95 ±[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15280016
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"The nuclear factor-kappa B (NF-kappaB) p65 pathway was inhibited by JSH-23, and the results showed that treatment with JSH-23 inhibited M1 macrophage differentiation and alleviated cardiac injury in LPS treated IL-5-knockout mice."
33043521