IndraLab

Statements

Curcumin inhibits CHUK. 9 / 9
2 | 7
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"Curcumin (10 muM) markedly inhibited IKK1 and IKK2 activity induced by LPS, whereas tetrahydrocurcumin (4H), hexahydrocurcumin (6H), and octahydrocurcumin (8H) showed a less inhibitory effect at the s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11077049
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"Curcumin, the yellow pigment derived from Curcuma longa, inhibited IKKalpha, IKKbeta and NIK, indicating its strong potential to block NF-kappaB-mediated cytokine release and the innate immune response."
15927892
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"Our data indicated that there is a reduced expression of IKKalpha and IKKbeta in tumor of mice treated with curcumin with respect to controls, indicating that curcumin inhibits NF-kappaB activation through suppression of IKK (XREF_FIG)."
24324975
ctd
No evidence text available
16219905
reach
"Our results demonstrated that oral administration of 0.05% curcumin significantly inhibited the up-regulation of IKKalpha, without affecting the expression level of IKKbeta, after I/R injury (XREF_FIG)."
21858029
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"Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active."
11077049
reach
"Taken together, these results indicate that curcumin blocks IKK-alpha activation through inhibition of an upstream protein kinase B (Akt)."
21669872
reach
"Our data also showed that curcumin inhibited the expression of several important proteins regulated by NF-kappaB; in particular, we demonstrated that there is a reduced expression of IKKalpha and IKKbeta in tumor of mice treated with curcumin with respect to controls, indicating that curcumin inhibits NF-kappaB activation through suppression of IKK in MIA PaCa-2 cells."
24324975
ctd
No evidence text available
16023083