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USP7 increases the amount of Ubiquitin. 4 / 4
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"Therefore, epigenetic mechanisms such as DNA methylation and histone modification are appealing targets for cervical cancer prevention and treatment.Many viruses, including HPV, induce the expression [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors."
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"XREF_BIBR Similarly, our further mechanistic investigations demonstrated that overexpression of USP7 increased the protein level of JMJD3 and its ubiquitin modification level."
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"More importantly, the ΔCD mutant, but not WT USP7, greatly increased the ubiquitin modification level of co-transfected RUNX3 ( Figure 5 G)."
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