IndraLab

Statements

E2 increases the amount of HCN1. 3 / 3
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"Two I h channel mRNAs, HCN1 and HCN2, are highly expressed in mouse GnRH neurons, and the mRNA expression of HCN1 is up-regulated by E2 [XREF_BIBR]."
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"But based on the increased HCN1 mRNA expression by E2, we would predict an E2 induced increase in I h amplitude."
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"Presently, we show that E2 augmented the excitability of Kiss1 ARH neurons by amplifying Cacna1g, Hcn1 and Hcn2 mRNA expression and T-type calcium and h-currents."
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