IndraLab

Statements

Calcium(2+) activates CACNA1S. 5 / 5
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"Enhanced mis splicing also occurred for Ryr2, which regulates calcium release from the sarcoplasmic reticulum and RYR2 mutations cause catecholaminergic polymorphic ventricular tachycardia, and Cacna1s, which was recently shown to be mis spliced in cardiac and skeletal muscle leading to aberrant gating of this Ca (V) 1.1 calcium channel."
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"Bulk RNA-seq analysis and two-photon microscope live calcium imaging reveal altered calcium signaling dynamics derived from ethanol-induced down-regulation of RYR1 and CACNA1S."
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"Additionally, lincomycin impacts calcium homeostasis by activating CACNA1S and ATP2A while inhibiting their inhibitor PLN , promoting Ca 2+ transport and storage, essential for cellular activities [44[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, we should stay open-minded to the possibility of other mechanisms by which mutant Ca 1.1 subunits may cause susceptibility to HypoPP."
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"We hypothesized, however, that the channel’s presence in the skeletal muscle sarcolemma might in some way modulate the current amplitude or abundance of the Cav1.1 Ca channels (DHPRs) also located there."
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